There are hundreds of thousands of cold cases in the United States. Traditional forensic testing frameworks such as CODIS won’t help solve them. But new DNA testing technology can. Othram operates at the intersection of molecular biology, population genetics, and bioinformatics. Bridging 20th-century population genetics and 21st-century data science, we are the first and only forensic laboratory to vertically integrate a DNA test and human ID solution, that can identify victims, find missing persons, and reveal perpetrators of crimes. Othram achieves results even when other approaches fail.